Custom atlases

Can we create custom population atlases for mutant vs. control cohorts?

Yes — NeuroSimplicity generates custom population-specific atlases directly from input cohorts, creating mathematically optimal averages for mutant, control, or treatment groups rather than forcing ill-fitting standard spaces.

Standard atlases (Allen CCFv3) do not always reflect specific phenotypes or developmental stages. Custom templates built from your cohort ensure registration targets faithfully represent your study population anatomy.

Combine with standard atlas alignment for publications requiring both common reference frames and study-specific templates.

Key capabilities

  • Custom mutant vs. control atlas generation
  • Population-specific template averaging
  • Registration to study-specific and standard atlases
  • Cohort comparison in native sample space
  • Support for novel phenotypes and developmental stages

Related resources

Custom Population Atlas Software | NeuroSimplicity