MRI · Anatomic imaging

How do preclinical labs analyze and process MRI data?

Preclinical MRI provides in vivo structural and functional anatomic contrast. You need to process those volumes: segment structures, compare time points or cohorts, and register them as an anatomic reference when correlative light-sheet, whole-slide histology, or spatial omics data come from the same study.

What researchers typically do

Most preclinical MRI stays in scanner reconstruction software or moves to ImageJ, ITK-SNAP, or custom pipelines per lab. That works for individual scans and exploratory analysis. Longitudinal cohort comparison, reproducible segmentation across operators, and using MRI as the anatomic anchor for ex vivo light-sheet, reconstructed histology, or spatial omics from the same specimen are harder to sustain outside study-specific scripts. Connecting those modalities in one auditable environment remains uncommon.

MRI as an anatomic reference in the Imaging Suite

With the NeuroSimplicity Anatomic Imaging Module, you can process preclinical MRI on institutional infrastructure with automated segmentation, atlas registration to the sample, and deterministic cohort pipelines. You can use MRI or micro-CT as the anatomic reference for registering light-sheet fluorescence, reconstructed whole-slide histology, and spatial omics from the same specimen. When you license the full Imaging Suite, you can integrate those modalities in one native sample-space framework.

What the platform enables

  • Preclinical MRI processing, visualization, and segmentation
  • Atlas registration to the sample in native sample space
  • MRI or micro-CT as anatomic reference for light-sheet, whole-slide histology, and spatial omics registration
  • Longitudinal and correlative study support
  • Cross-modal integration when the full Imaging Suite is licensed

More detail

MRI and micro-CT share the Anatomic Imaging Module. The first module you select is included in the base platform license; each additional module is an add-on.

To integrate MRI with light-sheet, whole-slide imaging, or spatial omics from the same specimen, see the multi-modal integration guide linked in Next steps.

Next steps

Preclinical MRI Analysis & Processing | NeuroSimplicity